![]() ![]() ![]() In Pakistan, potato is an important crop however its annual production is very low as compared to other countries. Potato ( Solanum tuberosum L.) is a starchy and most widely grown tuberous crop from the Solanaceae family worldwide ( Brown, 2005 Khorasani et al., 2008 Zaheer and Akhtar, 2016). Hence the applied in silico strategy led us to identify novel fungicides. Similarly increased disease control was observed in pre-treated potato tubers. Moreover in vitro trials showed that inhibitory effects were enhanced with increase in concentrations. The compounds were found to inhibit mycelial growth of A. Based on virtual screening results twelve commercially available compounds were purchased and tested in vitro and in vivo. The three dimensional SDH model showed good stereo-chemical and structural properties. We employed computational methodologies to design new SDH inhibitors using homology modeling pharmacophore modeling and structure based virtual screening. Hence targeting Alternaria solani SDH enzyme could be efficient tool to design novel fungicides against A. The enzyme Succinate dehydrogenase (SDH) is a potential drug target because of its role in tricarboxylic acid cycle. 6UoN Chair of Oman Medicinal Plants and Marine Products, University of Nizwa, Nizwa, OmanĪlternaria blight is an important foliage disease caused by Alternaria solani.5Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan.4Plant Breeding, Wageningen University and Research, Wageningen, Netherlands.3Department of Biochemistry, Kinnaird College for Women, Lahore, Pakistan. ![]() 2Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.1Institute of Agricultural Sciences, University of the Punjab, Lahore, Pakistan.Vleeshouwers 4 Ajmal Khan 5,6 * Ahmed Al-Harrasi 6 Shahbaz Ahmad 1 ![]()
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